Get help. Refer a patient. Find hope. 888-364-5977


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Find hope. 888-364-5977

October 08, 2015

What Do Genetics Have To Do With Eating Disorders?

by Mark Warren, M.D.

picture of DNA strands - Genetics685x350

A common fact shared with clients and their families is that eating disorders are genetic. When we use terms like "genetic," it often makes people wonder exactly how this illness might be inherited, especially if no close family members have the same illness. It also may make a parent wonder if there are hidden genetic factors that he/she passed onto the child, which could make a parent feel responsible for causing this illness.

The field of genetics is still young, but it has changed enormously in the last 20 years — and even more so in the last five. Much of what we used to believe was true about genes, genetics and inheritance of traits has turned out to be incorrect. What we do feel fairly certain about is if someone in your family has an eating disorder, it increases your risk for developing one. We also know there are specific genes that may be involved, although the evidence for this is early. However, even if we are able to identify certain genes associated with eating disorders, it is not clinically useful at this time.

Our traditional way of thinking is genes predict certain features for a person. The most obvious example is eye color. But it turns out that eye color is the exception, not the rule. It is very rare for single genes to code for single features. We think there are at most 35,000 genes in our DNA. That is a large number, but our expectation based on the human complexities is that we'd have millions.

Currently, theory suggests that our genes all work together, and there are complex mechanisms to determine when genes are turned on or off; how they interact with each other; and how the environment affects this complex interaction to produce who we are.

Imagine that genes are musical instruments in a gigantic symphony. Based on which instruments the genes play, when and what music, there is an infinite variety of music they can produce.

That is how we think about genetics. Genes do not code for complex behavioral syndromes, instead genes code for proteins. Which proteins and in which combinations and in what biochemical environment they are in determines how they are expressed. There are billions of ways they can be combined and expressed.

To develop an eating disorder, certain genes may need to be present and certain proteins may need to be produced. But, this by itself does not predict everything about the complex syndrome. This is why not everyone with these genes has the eating disorder. This is why not every eating disorder is the same as every other one. This is why some people do better in treatment than others.

To say something is genetic is to say it is not one single thing. Instead, it is to suggest that the orchestra will be more likely to play one type of music, but what actually happens in your life is far more complicated.

About the Author

Mark Warren, M.D.

Mark Warren, M.D.

Mark Warren is the chief medical officer of The Emily Program. He is also one of the original founders of the Cleveland Center for Eating Disorders, which became The Emily Program – Cleveland in 2014. A Cleveland native, he is a graduate of the Johns Hopkins University Medical School and completed his residency at Harvard Medical School. He served as Chairman of the Department of Psychiatry at Mt. Sinai Hospital and Medical Director of University Hospital Health System's Laurelwood Hospital. A past vice-chair for clinical affairs at the Case School of Medicine Department of Psychiatry, he continues on the Clinical Faculty of the Medical School, teaching in both the Departments of Psychiatry and Pediatrics. He is currently a faculty member and former chair of the Board of Governors at the Gestalt Institute of Cleveland. Dr. Warren is a Distinguished Fellow of the American Psychiatric Association, a two-time recipient of the Exemplary Psychiatrist Award of the national Alliance for the Mentally Ill, and a winner of the Woodruff Award. He leads the Males and Eating Disorders special interest group for the Academy of Eating Disorders.

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